Therapy successfully treats persistent epithelial defects

Additionally, researchers who conducted the review of 12 patients with corneal persistent epithelial defects (PEDs) secondary to infectious corneal ulcers, said the treatment can prevent continuous corneal melting during acute disease.{{quote-A:R-W:450-Q: The treatment can prevent continuous corneal melting during acute disease. }}During the study, patients were fitted for silicone hydrogel lenses and administered 20% ASEs bi-hourly during waking hours, along with prophylactic 0.5% levofloxacin ophthalmic solution four times each day. Using a slit lamp, the researchers recorded corneal epithelial healing every 1–3 days until complete corneal re-epithelialisation was visualised.All patients achieved complete re-epithelialisation within two weeks of the combined therapy, and no recurrence of an epithelial breakdown was observed during a three-month follow up.Prior to treatment, patients were administered several sole agents, including artificial tears or lubricating gel/ointment, before receiving combined therapy and all proved unsuccessful.However, despite the success of the treatment, corneal scraping and cultures revealed Pseudomonas aeruginosa, Streptococcus pneumonia and Staphylococcus aureus in nine of 12 patients.