New study finds natural compound can clear up cataracts

While scientists don’t fully understand where they come from, cataracts are believed to be formed from defective proteins that clump together and obstruct the crystaline lens and cause an effect on vision.It took molecular biologist Professor Khang Zang, MD, PhD at UCSD’s Shiley Eye Institute and other researchers years to come up with the new treatment, based on lanosterol, a naturally-occurring steroid.Prof Zang headed a series of tests with human lens cells and found that the lanosterol drops caused cataracts to become smaller in size. Next, the team carried out experiments on rabbits, and 11 of 13 subjects showed progress when given the drops.Lastly, scientists administered the treatment to various breeds of dogs with naturally-occurring cataracts; three out of seven dogs tested had their sense of vision returned while another four dogs’ cataracts nearly dissolved six weeks into treatment. This is a really comprehensive and compelling paper – the strongest I’ve seen of its kind in a decade, Professor Jonathan King, PhD, a molecular biologist at Massachusetts Institute of Technology not affiliated with the study, said. He has been investigating cataract proteins since 2000. They discovered the phenomena and then followed with all of the experiments that you should do – that’s as biologically relevant as you can get.The number of people suffering from cataracts worldwide is growing as well. According to the World Health Organization, cataract is the most common causes of blindness and visual impairment worldwide, with 47.9% of those with impaired vision afflicted.Despite recent progress in medicine, cataract surgery, inaccessible for many of the 20 million blind people around the world, has been the only treatment option.Ruben Abagyan, molecular biologist at UC San Diego, has high hopes for the drug’s development. I think the natural next step is looking to translate it into humans,? he said. There’s nothing more exciting than that.