Scientists at the University of East Anglia (UEA), in collaboration with Hoya Surgical Optics, say they can now examine levels of posterior capsule opacification (PCO) – a clouding effect that can develop post-operation – in commercially available IOLs.Lead researcher Professor Michael Wormstone, from the UEA’s School of Biological Sciences, said the human capsular bag model was pioneered in the 1990s to simulate cataract surgery using human donor eyes. Over the past two decades it has evolved to better mimic the events that lead to PCO complications.“[The model] is more reflective of clinical events and allows comparative evaluation of different types of IOLs. We believe this latest model will allow assessment of current commercial IOLs and will aid the development of next generation lenses,” he said.Wormstone’s comments come after his research team applied the model to compare the influence of two market-leading IOLs – Alcon AcrysofTM and Hoya VivinexTM – on PCO managent.In comparing the devices, the Hoya device resulted in reduced cell growth on the posterior capsule, lower levels of light-scatter in the central visual axis and significantly reduced growth on the IOL surface.“Our model syst predicts that the Hoya VivinexTM is better able to manage events leading to PCO than the Alcon AcrysofTM IOL”,” the researchers stated.The research, which was funded by Hoya Surgical Optics and The Humane Research Trust, has been published in the journal Investigative Ophthalmology and Visual Science.
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