Bayer and Reageneron to develop new treatment option for wet AMD

“Bayer has been a great collaborator in the development and commercialization of Eylea outside the United States,” Dr George Yancopoulos, MD, PhD, chief scientific officer of Regeneron Pharmaceuticals and president of Regeneron Laboratories, said. “We look forward to building on our relationship in ophthalmology with this potential next generation product candidate which will combine Regeneron’s PDGFR-beta antibody and Eylea in a single intravitreal injection.”Given the multi-factorial nature of wet AMD, there is a potential for additional benefits to patients by addressing different pathways responsible for this devastating condition,” Dr Kal Malik, MD, a mber of the Bayer HealthCare executive committee and head of global development, said.”Inhibition of PDGF is one such pathway and we are looking forward to developing a potential combination therapy together with Regeneron. Bayer is strongly committed to expanding its ophthalmology research and development efforts with innovative treatment options and this new development candidate complents our own pipeline perfectly.”Under the terms of the agreent, Bayer HealthCare will make an upfront payment of $US25.5 million to Regeneron and will share global development costs for the program.Bayer HealthCare will have exclusive commercialisation rights to the combination product outside the United States where they will share profits from ex-US sales equally with Regeneron.Within the US, Regeneron has exclusive commercialisation rights and will retain 100 per cent of the profits from sales.Under the agreent, Regeneron is eligible to receive up to $US40 million in option and milestone payments through regulatory approval from Bayer HealthCare, and Bayer HealthCare is responsible for certain payments due a third party, including royalties on ex-US sales and a share of development milestones.

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